The historic Bruheze was a hamlet consisting of a few farms on the present Bruhezerweg. Later, the surrounding hamlets were also counted as Brouwhuis. This 'large brewery' was therefore divided among the glories, parishes and later municipalities of Bakel and Vlierden. Between 1926 and 1967 the Vlierdense part belonged to the municipality of Deurne.
In the Middle Ages in the Vlierdense area there was a lock Bruheze, from which the name of the Van Bruheze family was derived. According to legend, Maria van Brabant donated this lock to a courtier, Justus van Horne, when he married the maid of honor Catharina van Benthem. The descendants of Justus then called themselves "van Bruheze". It is not clear to what extent this legend is true, but the coordination of the Van Bruhezes from the Van Hornes is likely. They developed into a well-known late medieval knighthood. Over the centuries, the name "Bruheze" became "Brouwhuis" (in the Brouwes dialect), a name that became official in 1830 when it was included as such in the land register map.
After Brouwhuis had grown into a community that was also located on a tram line, a need arose for its own school and church. The church, dedicated to Our Lady Mediator of All Graces, was finished in 1929, a few hundred meters west of the old hamlet. It was first a rectoral auxiliary church, served by the Fathers of the Sacred Heart of Jesus (SCJ), but later Brouwhuis developed into an independent parish. The fathers encouraged the worship of Saint Gerardus Majella, who got his own chapel in the church. Soon a modest place of pilgrimage arose. In 1933 there was even a kind of procession to the church of Brouwhuis. After 1960 interest in pilgrimage fell, and in 1970 it was abolished de facto, although the devotion to Saint Gerardus remained in a certain sense.
A village center arose around the church, school and tram line. In 1968, both the Bakel and Vlierden parts of Brouwhuis were added to the Helmond growth center. As a result, Brouwhuis became an administrative unit for the first time, after it had already become parochial.
From the 80s of the 20th century, housing construction and development of business parks started. The relocation of the Zuid-Willemsvaart and the construction of the Rochadeweg were part of this plan. The village center was fitted into the new residential area. Various more remote hamlets, such as the Achterste Beersdonk, were demolished between 1995 and 2004 to make way for business parks. Others, such as Peeleik, were fitted into the existing buildings.
Today the Brouwhuis parish, together with the parish of Saint Edith Stein, forms the Brouwhuis-Rijpelberg parish.