Going up the first stretch of via Vittorio Emanuele, which runs alongside the church of San Giuliano, you come to a large crossroads overlooked by the church of Santo Isidoro Agricola. Founded in 1626 by the company of the burghers of Calatafimi, that is the farmers of Calatafimi in honor of their Patron, "Santo Isidoro", who was himself a farmer, who until then had venerated their saint in the mother church. In it was located the Congregation of Maria SS. degli Agonizzanti, canvas founded in 1672. The original façade of the church was rebuilt in 1944 to a design by the architect Vincenzo Mangano. On the façade, wedged into the architrave of the entrance door, there is a high relief, almost in the round, about 1.20 m in height, depicting the Saint of Labrador, "Santo Isidoro", with two yoked oxen at the bottom, in the the act in which he strikes the arid ground with a stick and causes an abundant gush of water to flow from it. Inside on the left, we still find a marble source for blessed water with St. Sebastian, the Madonna and Child, the coat of arms of the city. Overlooking the figure of the saint is a feast of baroque angels. And the whole thing is softly baroque”. The sixteenth-century church in the internal architecture, Baroque in the rich and very soft stuccos, once patinated with gold, which decorate vaults, walls, windows and altars, is today closed to worship. Some of the paintings, statues and a stoup it kept are today exhibited for worship in the church of San Michele.