The town located at the foothills of Mount Pincio was owned by the Della Faggiola family and later by the Malatesta family.
It is a possession of the Feretrana church until 1296, when the Ghibelline Maghinardo Pagani, leading Rimini and Montefeltrani together (a rare case in the history of these lands) managed to conquer it. The dominion did not last long and Talamello was again subjugated to Rome. It was enfeoffed by the supreme pontiff to Uguccione della Faggiola, coming under the control of the family.
It was Cardinal Egidio Albornoz who took it back in 1355. In 1390 the castle was sold to Galeotto Malatesta and then confirmed in 1416 to Carlo Malatesta. Pius II gave it fief, like other neighboring villages taken from Sigismondo Pandolfo Malatesta, the Guidi di Bagno and the Malatesta di Sogliano. With them (1490) the production of gunpowder in the Talamello mills "began" which will end in the second half of the twentieth century, after about 500 years of activity. The small cemetery close enough to the town certainly deserves attention. , in which there is the cell that contains small artistic treasures: in fact it is completely decorated with frescoes, dated 1437, by Antonio Alberti from Ferrara. In Talamello there is also a splendid 14th century Crucifix which, every Whit Monday, carried in procession, attracts faithful from all over the neighboring area; many believe that the author of this Crucifix is Giotto, but in reality it seems to be attributable to Giovanni da Rimini and painted in 1300.
It is kept on the main altar of the seventeenth-century parish church of San Lorenzo; also in this small but precious church you can admire a 15th century Madonna and Child, a beautiful polychrome wooden statue, and an equally well made wooden crucifix from the 16th century.
The prestigious pictorial heritage of Talamello was enriched in 2002 with the opening of the Gualtieri "The splendor of the real" museum-art gallery, consisting of over 40 canvases that the Talamello-born painter Fernando Gualtieri donated by the Municipality.