The estate was founded in the first third of the 17th century by the landowner A. Vsevolozhsky.
Under the actual state councilor Alexei Stepanovich Vsevolozhsky (1699-1760), the estate complex was formed. After the death of Alexei Stepanovich and his wife Maria Ivanovna, Zherekhovo was inherited by their sons Vsevolod and Sergei. Vsevolod and Sergei, along with their brothers, were among the participants in the coup of 1762, for which they received numerous awards, estates and ranks from Catherine II.
The last owner of the estate from the Vsevolozhsky family was the son of Sergei Alekseevich - Nikolai (1772-1857), who inherited Zherekhovo in 1807. He was one of the most educated people of his time: a historian, writer, a keen bibliophile, who collected a unique library, the books from which were decorated with rare in their beauty ex-libris.
In April 1848, Nikolai Vsevolozhsky sold the estate to Count Valerian Nikolaevich Zubov (1804–1857), the grandson of A. V. Suvorov. The purchase of the estate was not accidental. The Zubov estate, Fetinino, was located nearby, which Valerian Nikolaevich inherited from his mother. In 1831, Valerian Nikolaevich married Countess E. A. Obolenskaya (1811–1843), the daughter of the actual privy councilor A. P. Obolensky and A. Yu. Valerian Nikolaevich Zubov had no heirs. According to his will, the estate in 1857 passed to his niece, Princess Natalia Vladimirovna Obolenskaya (née Mezentseva), Suvorov’s great-granddaughter. Natalia Vladimirovna's husband, Sergei Alexandrovich, bore the triple surname Obolensky-Neledinsky-Meletsky from 1870 with the permission of the emperor.
The Zherekhovo estate was inherited by Sergei Alexandrovich's youngest son, Platon Sergeevich (1850-1913), a major general. The estate belonged to the Obolensky-Neledinsky-Meletskys until 1917.
The estate complex in Zherekhovo was formed under Alexei Stepanovich Vsevolozhsky. In 1731, a stone church was erected, in the 1760s a large stone house with outbuildings was built, a stud farm was opened, a garden was planted, and a regular park was laid out in the form of an oblong rectangle, dissected by geometrically symmetrical alleys.
The main estate house was built in the Baroque style. In the 1830s, two-story semicircular galleries with three-story towers and two staircase-ramps in the Gothic style were added to it. This was probably done by the provincial architect E. Ya. Petrov, a student of M. F. Kazakov. In the 1920s, artistic treasures were removed from the estate and included in the collection of the Vladimir-Suzdal Museum-Reserve.