Built in 1920 to replace the chapel of the same name that stood in the lake in front of the church today. According to tradition, the chapel was destroyed with the Ottoman conquest of the city in the 14th century to make way for a mosque. However, on the feast of Saint Barbara, the area flooded, creating a lake that covered the construction site. Thus, Saint Barbara was declared the patron saint of Drama, and years later, after the Ottomans withdrew, this new church dedicated to the saint was built.