Gregorio Luperón (* September 8, 1839 in Puerto Plata; † May 21, 1897) was a Dominican military man and state leader. He was the 20th president of the state.
Luperón pursued a military career and was a general in the Restoration War from 1863 to 1865. Ulises Francisco Espaillat suggested that he run for president in 1876, but Luperón initially declined. From October 6, 1879 to September 1, 1880, he was interim president. Under his successor Fernando Arturo de Meriño, he eventually became a diplomat in France.
Puerto Plata Airport (Aeropuerto Gregorio Luperón) and the Gregorio Luperón High School for Math & Science in New York are named after him.