The church, which was built in the 13th century, was originally a single-nave structure made of granite blocks. From around 1300, it was extended with a northern annex, creating an elongated brick building with two aisles of unequal width. The nave and presbytery are separated by a brick rood screen. The wood of the undamaged roof truss was dendrochronologically dated around 1440, which suggests that the roof was built at the beginning of the 15th century. The church served as the burial place of several noble families from Mark.
In the 15th century disputes over poverty in the Franciscan Order, the Franciscans of Angermünde took a stricter line. They long resisted the Reformation introduced in Brandenburg by Elector Joachim II in 1539. It was only in 1556 that the Provincial Superior of the Saxon Franciscan Province had his seat in the monastery in Angermünde. In the same year, the last Franciscans had to leave the monastery, and the elector donated the monastery to Hans Flanß, captain of Beelitz, who in 1567 sold it to the city of Angermünde for 1,000 Reichstallers.
The church and monastery fell into ruin. With the Huguenot settlement in Uckermark, the church was restored and partially used as a Reformed church in 1699-1788.
The choir was already used by the military as a warehouse from 1725. The demolition of the monastery from the south with two cloisters was initiated by the city council in 1767; the stones were used to build the factory on Schwedter Tor. The vaults of the church were pulled down in 1825. In the nineteenth century, restoration began at the initiative of King Frederick William IV. Conservation work also took place during the times of National Socialism. After the reunification of Germany, the monastery church was turned into an auditorium.