This hermitage is believed to have been founded at the beginning of the 17th century, as a sign of the great faith and devotion of its citizens towards the Holy Trinity, demonstrated through wills, memory foundations and chaplaincies, always including the same phrase "in the name of the Most Holy Trinity, Father, Son and Holy Spirit, three persons, one true God".
Hermitage located on the road to Sta. Cruz de Mudela. It was run and assisted by the Trinitarian fathers, who in turn depended on the convent of the Holy Trinity in the town of Membrilla.
During the 19th century it was forgotten and left in a dilapidated state. Don Santiago Julio Maldonado y Maldonado-Cisneros, law graduate, natural and resident of the town, in his will when he died on December 10, 1886, ordered that the Hermitage of the Santísima Trinidad y San Antón be rebuilt at his expense, where the mortal remains of the testate, of his deceased parents (D. Santiago Maldonado Treviño and Dª María Antonia Maldonado Cisneros), of his wife (Dª Pilar Forcallo y Morales) and other successors in the board of trustees, ordered the construction of a building immediately next to the Hermitage of San Antón (Santísima Trinidad), which will have the shape and proportions of the plan, whose building would be used as a Hospital for the poor, and the family designated by their heirs must reside in it, in order to attend to its conservation and cleaning and whose family should be natural and neighbor of the Villa.