The house was the seat of the Teutonic Order in the Upper Town from the mid-13th to the mid-16th century. From February 1525 to May 1525, it became the residence of Thomas Müntzer. In St. Mary's Church opposite, the reformer, who was well known alongside Martin Luther, preached and placed the city at the center of German history during the Peasants' War. After the Teutonic Order left, the building became the rectory of St. Mary's until 1975.
Friedrich August Stüler was born here on January 28, 1800. Stüler was one of the most important architects of his time. In addition to the Neues Museum in Berlin, the "architect to King" Frederick William IV designed numerous churches and manor houses in Brandenburg, but the busy Mühlhausen native was also regularly active internationally.
Today, the house houses the administrative headquarters of the Mühlhausen Church District.