The church was built between 1473 and 1529 and was later transformed in the 17th and 18th centuries. The facade and the portico, dating back to 1687, are the work of the Tifernate architect Nicola Barbioni. Of the primitive construction, completed thanks to the precious contribution of Bishop Giulio Vitelli, remains the portal and the cloister in the center of which there is a well-preserved cistern that bears an ancient inscription and a date: DOMINUS JULIUS DE VITELLIS MDXXVI. From the convent and the church of the Zoccolanti come several glazed terracotta from the workshop of Andrea della Robbia, currently preserved in the Municipal Art Gallery. Under the portico of the facade of the church there is a copy of San Giovanni Battista made by Donatello in 1457 for the Cathedral of Siena. Also this religious complex, as proof of the deep attachment of the Tifernati towards the Franciscans, was built with the help of the local population and also had the protection of noble families. It is said that Angela Rossi of the Counts of San Secondo Parmense, mother of Cardinal Vitellozzo Vitelli, had the road that led from the city to the convent built in just one night.