Since Neerloon is located directly on the Maas, this river has been of great importance to the history of the village. Neerloon is one of three places in North Brabant where there used to be a ford in the river.
The Romans already used this walkable place, which is called a statio in Latin. The Staaystraat is still a reminder of this.
The oldest mention of the Neerloon settlement dates from 1191.
The Maas meandered through the landscape and had many bends. Between 800 and 1200 the village was surrounded by water and Neerloon was therefore an island.
In the late Middle Ages, from 1334, Neerloon formed a Land van Cuijk enclave in the Land of Ravenstein. Completely on the other side of the Land van Cuijk was another Loon: Overloon. The first charter of aldermen dates from 1358.
Neerloon's right of patronage belonged to the chapter of the St. Victor Church in Xanten. This is why the parish church of Neerloon is dedicated to this saint. This chapter already owned a farm in Neerloon in the 13th century. St. Victor's Church was first mentioned in 1405 as a quarta cappella.
Neerloon suffered greatly from flooding from the Beerse Maas. In 1803, a quay was constructed to protect the Neerloon Polder against this. Nevertheless, a serious flood occurred in 1820, which largely destroyed the parish church.
From 1811 to 1923, Neerloon was part of the municipality of Huisseling and Neerloon. The municipality was then annexed by Ravenstein, which in turn was annexed by Oss in 2003.