The mention of Rode appears in a letter from 1110 when the Berthouts, lords of Grimbergen, transferred the 'altare de Mensce' together with its dependencies Oppem and Rode to Bishop Odo van Kamerijk. Meise then came under the patronage of the church of Grimbergen. When the abbey of Grimbergen was founded in 1127, this was accompanied by the transfer of the aforementioned goods (1132). In 1838, Sint-Brixius-Rode finally became independent of the parish of Meise and was given its own rectory.
As early as the 11th century, there was mention of a church with a wooden tower. In the 13th century, a stone church was started, which was mainly modified and expanded in the 15th and 17th centuries. For example, the church was significantly enlarged in 1655 with the support of Count Eugeen de Berghe, lord of Sint-Brixius-Rode, see coat of arms in the west facade. When the church had become very dilapidated at the end of the 19th century, urgent restoration work was necessary. In the period 1907-1908, the church underwent a thorough transformation in neo-Gothic style, carried out according to the plans of architect F. Symons (1869-1942). The windows and roofing in particular were thoroughly modified. Previously, the church had pointed arch windows that were changed into neo-Gothic pointed arch windows with tracery. The choir, which was previously shorter and provided with the date 1749, was extended with a sacristy.
(Inventory of Immovable Heritage)