The construction of the Marienkapelle was begun in 1377 and completed with the tower built around 1480. Originally, a chapel was built at this point for atonement by the citizens. Thus, the building remained without parish rights and is entitled "Chapel". Also the "Kramläden", which exist today, were already created in 1437.
In the arc fields of the portals one finds rich plastic Bauzier. Particularly noteworthy here are the figures Adam and Eve, which were made by sculptor Tilman Riemenschneider. The originals can be visited today in the Mainfränkisches Museum, they were replaced in 1975 by copies.
After the fire in 1945, during which the entire roof truss and the wooden interior were burned, the Marienkapelle was completely refurbished. On the altars there are four panel paintings from 1514.
Significant here is the silver Madonna above the altar of the northern aisle, created in 1680 by Johann Kilian. In the aisles there are numerous tombs Frankish knights and Würzburg citizens, including the tomb of Konrad von Schaumberg († 1499) by Riemenschneider. At the market portal, a bronze commemorative plaque points to the burial place of the great Baroque architect Balthasar Neumann (1687 - 1753).