The pilgrimage church Madonna del Sangue consists essentially of two churches. The older part, built between 1606 and 1628, is a single-nave basilica with portico. This church is dedicated to San Maurizio, was built in place of a smaller previous building and has the altar with the image of the bleeding Madonna (Madonna del Sangue). The Madonna image recalls the miracle of April 29, 1494. An angry citizen of Re, who had previously failed in the game, had thrown a stone at the Madonna portrait. Thereafter, this portrait is said to have cried tears of blood for twenty days.
Immediately afterwards, the second, much larger church from the 20th century stands without spatial separation. Also from here the altar with the bleeding Madonna can be seen. At the end of the 19th century, 400 years after the miracle of Re, the pilgrimage church was no longer large enough to accommodate all pilgrims. The then pastor Don Giovanni Antonio Peretti, therefore sat down with emphasis for the construction of a larger pilgrimage church. For the imposing sacred building, a few residential buildings and stables had to be demolished first. In 1922, the foundation stone was laid under the direction of Bologna architect Edoardo Collamarini. The inauguration of the new, widely visible pilgrimage church with Byzantine domes and neo-Gothic pointed arches was held on 5 August 1958 by the Bishop of Novara.