The first mention of Auressio dates back to 1233 with the name Oraxio.
Since the Middle Ages, Auressio, together with the villages of Verscio, Cavigliano and, until 1464, Tegna, formed the municipality of Pedemonte. However, Auressio enjoyed a certain degree of autonomy. During the 18th century, Auressio sent a representative to the Locarno Parish Council every eight years. In September 1800, in Auressio, there were the first signs of an uprising in the Onsernone Valley against the Swiss regiments and against the French occupying troops in Ticino. The prefect of Lugano ordered the military occupation of Auressio and the extradition of eight citizens. A force of 50 militiamen tasked with carrying out the order was greeted by the valley's farmers with a hailstorm of stones rolled from the mountain. The second attempt was unsuccessful due to heavy rain. Only on the third attempt was it possible to occupy the village, but the perpetrators had already left the area.
Auressio was part of the religious community of San Fedele di Pedemonte (Verscio) and was not recorded when it was dissolved. The church of Sant'Antonio Abate was perhaps built in the Middle Ages and was inaugurated in 1526. In 1701 the portal was built and in 1775 the side chapels and the bell tower. Until 1792 the church was a joint parish with Loco, and in that year the two parishes were separated. In the years 1868 to 1870 the ceiling was repaired and in 1876 the clock of the bell tower was built thanks to the financing of Paolo Antonio Calzonio. The niche above the entrance to the church with the statue of Saint Antonio Abate dates from 1891.