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Los Santos Ángeles de Guevavi, established in 1691 by Jesuit Fathers Kino and Salvatierra, was one of the earliest Spanish missions in Arizona. It served as a district headquarters from 1701, with Father Juan de San Martin as the first resident priest. Over the years, the priests and residents faced hardships like disease, Apache raids, and the Pima revolt, a well-coordinated attack on Spanish missions and settlements by O'odham rebels in 1751. Despite efforts to sustain the mission, it was eventually abandoned in 1775. Its ruins were incorporated into Tumacácori National Historical Park in 1990, and were donated by Ralph Wingfield and preserved by the Archaeological Conservancy.

Nogales, Arizona, is a city in Santa Cruz County located directly on the U.S.-Mexico border. This high desert city, situated at an elevation of approximately 3,865 feet, serves as a crucial border crossing and trade hub. Established in the late 19th century, Nogales' growth accelerated with the arrival of the railroad in the 1880s. This connection fostered its development as a key point for U.S.-Mexico trade, particularly in fresh produce and cross-border manufacturing. Culturally, Nogales reflects its deep ties with Mexico. The city's rich cultural heritage is celebrated through various events and historic sites, such as the Old Courthouse and downtown's historic buildings.

Sonoita, AZ, nestled in the rolling hills of southeastern Arizona, is a hub for wine enthusiasts, rodeo lovers, and cyclists. As Arizona’s first American Viticultural Area (AVA), Sonoita boasts numerous vineyards and wineries, producing award-winning wines that draw visitors for tastings and tours. This picturesque region is known for its unique terroir, offering a variety of reds, whites, and rosés. Sonoita is also famous for its vibrant rodeo culture, with events like the Sonoita Horse Races and the Labor Day Rodeo showcasing traditional Western skills and attracting competitors and spectators alike. Cycling enthusiasts flock to Sonoita for its scenic routes and challenging terrains, making it a popular destination for road and mountain biking. The annual Tour de Tucson, a major cycling event, often features routes through Sonoita, highlighting its beautiful landscapes and cycling-friendly roads.

Patagonia is a sweet little Arizona Trail access town. It's a mix of miners, ranchers, folks living off the land, birders and cyclists.

The Arizona Trail leads directly through the small town of Patagonia. At Patagonia Market (open from 5am until 8pm!) and Red Mountains Foods you can refill your supplies. The only hotel in town is the Stage Stop Inn, which offers a discount for AZT hikers/bikers and has a hiker box available. If the hotel is fully booked, comfortable accommodation is available through AirBnB. Wifi and a great breakfast is available at the Gathering Grounds.

The Arizona Trail leads right through the small town of Patagonia. Patagonia Market (open from 5 in the morning until 8 in the evening!) And Red Mountains Foods will fill up your supplies. The only hotel in the city is the Stage Stop Inn, which offers a discount for AZT Hiker and a Hiker box. If the hotel is fully booked, there are comfortable accommodations via AirBnB. Wi-Fi and a great breakfast are available at Gathering Grounds.