The Jews in Hranice never formed a large group in relation to the total population, yet their social influence in the 19th century was very strong, especially in the development of Hranice industry. Until the mid-20th century, the largest Hranice factory was the textile factory of the Jewish Heller family (later Karnola), founded in 1844, and the liqueur factories of Sigmund Wolf and Abraham Wolf had an even longer tradition.
The original small brick synagogue building was replaced in 1863 by a new building in the then Moorish-Byzantine style. It then served as a place of worship until 1940. Fortunately, subsequent plans to demolish it were not implemented and in 1943 it was adapted to the needs of the city museum. It was brought to its current impressive appearance, thanks to which it is one of the characteristic dominants of the historical center, by a successful reconstruction in the mid-1990s. For almost thirty years it served as a gallery for organizing art exhibitions. Occasionally cultural events are held here. From January 1, 2024, the building of the Hranice synagogue will pass into the hands of the owner, who is the Czechoslovak Hussite Church.