With the bull "Sacrae religionis" of September 1471, Pope Sixtus IV granted the Friars Minor of the Regular Observance to accept the church already built in honor of St. Francis and to live in the adjoining convent.
In 1603, Pope Clemente ordered that the convent built by the Observant Friars should also inhabited by the Friars of the Sephardic Reformation. Immediately, the Friars of the new Reform, according to their rigid beliefs of poverty, carried out the transformation and completion of the convent. Above the corridor of the first floor, a suggestive viewpoint towards the city was built, configured as a covered veranda, marked by a flight of round arches.
In 1726, the quadriportico was frescoed by Giovan Battista Conversi from Matera.