The Boulder Mail Trail follows the historic mail and telegraph route between Boulder and Escalante, passing through canyons like Sand Creek, Death Hollow, and Mamie Creek. Hikers can find filterable water in Sand Creek, Death Hollow, Mamie Creek, and occasionally in pools on Antone Flat. Poison ivy is common in some areas, and summer temperatures can get high, making spring, fall, and winter the best seasons for hiking this trail, as long as there is also no snow on the ground.