According to tradition, it was built in 1348 as thanks to the Virgin of Mercy for the narrow escape from the terrible plague that raged throughout Italy in those years, the same one mentioned by Boccaccio in the Decameron.
The late Romanesque church was restored or rebuilt from scratch in the sixteenth century and a small hospital was added, which must have still existed at the beginning of the nineteenth century, as mentioned by the historian Nicola Palma from Teramo. The church has a very simple appearance on the outside, with lean and square walls and an apse with a nine-sided polygonal external plan.
The façade, with exposed brick and gabled roof, is characterized by a sober Renaissance portal. The interior has a single spacious nave divided into two lunette spans with a cross vault that is connected to the presbyteral space, slightly raised and to the vast apse by means of an arch.
The walls and the vault are frescoed with a cycle of frescoes, only partially preserved, which develops the theme of the Life of Jesus and the Redemption of Humanity, a work completed on 26 September 1526 by the Renaissance painter Giacomo Bonfini da Patrignone of Montalto Marche (1470 -1557).