It was built in the 14th century, when the Emperor Charles IV founded the castle of Montecarlo. The original building, of which only the façade with large square blocks of sandstone remains with a portal completed by a two-tone bezel, was in poor condition in the mid-17th century. Despite this it was restored only at the end of the eighteenth century and the decorative apparatus was completed in the second half of the nineteenth century.
Some of the most precious works are preserved in the chapel of the Madonna del Rosario, among which the most interesting are the statue of Sant'Antonio Abate by Francesco di Valdambrino (first decade of the fifteenth century) and the table with the Madonna Enthroned with Child by Francesco Anguilla ( 1434) which is the centerpiece of a polyptych whose sides are located in Birmingham, in the US state of Alabama. In the church is also one of Antonio Franchi's masterpieces, the altarpiece with Saints Lucia, Giovanni Battista, Francesco Saverio, Biagio and Gaetano signed and dated 1673