Nestled on the shores of Lake Marion, Santee is a laid-back destination known for its outdoor recreation and Southern hospitality. Visitors can fish, kayak, or take a boat tour on South Carolina’s largest lake, home to abundant wildlife and record-breaking catches. Nearby, Santee State Park offers lakeside cabins, nature trails, and easy water access, while the Santee National Wildlife Refuge invites birders and nature lovers to explore cypress swamps and historic Native American mounds.