Antazavė Manor was founded at the end of the 18th century at the initiative of Counts Pliaterii of German origin. At that time, the three-story neoclassical style white manor house was decorated with the coat of arms of Pliaterii. A stone barn, barns, cellars and other outbuildings were built next to the manor. A three-terrace park was planted on the foothills of Lake Zalvė, an oval-shaped flower garden surrounded by a wide path was installed on the main side of the palace facade, and two ponds were dug a little further and a bridge connecting them was built. The road to the manor was planted with chestnut trees. Count Ludvikas Pliateris managed the manor in 1763-1788. After his death, the estate passed to his widow, Kunigunda Vollovič Pliaterinei. In 1794, the countess financed the construction of the Antazavė church, parsonage, and hospital and gave land to build a cemetery. František Ksaveras Pliateri - Emilija Pliaterytė's father - one of the three sons of Kunigunda and Ludvik Pliaterii grew up in this estate. In 1831, during the uprising, rebels were gathered in the Antazavė estate. One of the participants of the uprising was Emilija Pliaterytė - known by the nickname of the Lithuanian Joan of Arc. A boarding school has been operating here since 1961. A little later, on the initiative of local researcher Stanislava Kirailitė, a museum was established on the second floor of the manor house, where archival and memorial materials about the history of the Antazavė region, manor, church and parish were exhibited, as well as detailed material about Counts Pliateri, their dynasty and famous local people.
Currently, a center for traditional crafts of the Zarasai region has been established in the manor, where woodcarving, weaving, and ceramics workshops are set up, and artisan exhibitions and classes are held.