The Regional Museum in Brzeziny was established in 1972 on the initiative of members of the Society of Friends of the Brzeziny Land. The Society members began collecting exhibits and historical documents in 1965, creating the nucleus of the museum collection. The founder and long-time director of the institution was ethnographer Elżbieta Putyńska, then the museum was managed by historian Jerzy Kołodziej. The museum's original location was a small premises of the former Kindergarten No. 1, located on a property at 49 Świerczewskiego Street (currently 49 Piłsudskiego Street). It was not until 1981 that it was possible to open a neo-Gothic palace adapted for the needs of the museum and located on the same plot - undoubtedly the most interesting non-sacral monument in Brzeziny. The palace was built on the site of an old wooden manor house, which belonged to the famous Buyn family and was the birthplace of the writer Maria Buyno-Arctowa and her brother Adam, Józef Piłsudski's companion in the PPS supreme authorities. In 1899, the Buyns sold the manor house to the district architect Karol Kleiber, who completely rebuilt it into a hunting palace in 1903. In the interwar period, after Kleiber sold the estate, the building housed the Brzezińska Kasa Chorych, and during the occupation, the Hitlerjungend organization had its headquarters here. After liberation, the ZHP Scout Troop operated in the palace for a short time, then, until the mid-1970s, the building was designated for tenant flats.