In a municipality located in the Tierteafuera River valley. In the heart of the Guadiana basin, framed and partially divided by the Grande and Chico streams, two kilometers from the Guadiana River. There is evidence of habitation in this area since pre-Roman times, as evidenced by the presence of several castles, such as Castillo and Castilnegro, and even a mound discovered in the 1970s and located at the edge of town.
La Puebla de Don Rodrigo is located just south of the Montes de Toledo and close to its core is the passage of the Río Guadiana, one of the most important in the peninsula.