The first wooden church in Uhów was built and consecrated in 1753 by the suffragan bishop of Łuck and at the same time the parish priest of Surasia, Ludwik Riaucour. In that year, metric books began to be kept and Uhowo became a branch of Suraż. Since the tsarist authorities did not allow the creation of a parish, Uhowo was a branch until Poland regained its independence.
In 1904, parishioners began applying for permission to build a new church. The project of a single-tower temple in the neo-Gothic style was prepared by architect Romuald Lenczewski. After several refusals to issue a building permit, e.g. for the participation of the inhabitants of Uhów in the January Uprising, a positive decision came only in 1914. In the same year, the parish priest, Fr. Stanisław Klim started construction works. The investment was interrupted during the war. From 1917, the construction was led by a new parish priest, Fr. Adam Abramowicz. On August 15, 1919, the temple was consecrated, and on August 8, 1921, it was consecrated by Bishop Jerzy Matulewicz.
From war damage, especially from 1944, the church was rebuilt by Fr. Edward Kisiel, who was the vicar of the old and ailing parish priest, Fr. Antoni Sałatyński. During the time of Fr. prob. Tadeusz Baluk, a general renovation of the church was carried out and a new rectory was built.
Text information comes from the website of the Archdiocese of Bialystok.